Microscopy Quotes

There are many cells you could look at forever in 3D.

You'd need a very specialized electron microscope to get down to the level to actually see a single strand of DNA.

I think if I weren't so squeamish, I would have been some sort of forensic analyst. And I can't do anything with a microscope, because then I start thinking about the world of germs around us.

The idea was to study fertilization in as many different phyla and organisms as possible, using the simplest possible equipment and a microscope. Biochemical approaches were not much in vogue, and running gels impossible at first.

Until 1930 or thereabout biologists [using microscopes], in the situation of Astronomers and Astrophysicists, were permitted to see the objects of their interest, but not to touch them; the cell was as distant from us, as the stars and galaxies were from them.

Like you can't have a car that can take the kids to schools on Friday and win the grand prix on Saturday, you can't make a microscope that can do it all.

I have a Ph.D. in cell biology. And that's really manual labor. I mean, experimental science, you do it with your hands. So it's very different. You're out there in a lab, cleaning test tubes, and it just wasn't that fascinating.

Before I went to bed, I sat up till 2 a-clock in my chamber, reading of Mr. Hooke's Microscopical Observations, the most ingenious book that I ever read in my life.

One thing I liked about being in microscopy is it gets you out of your box constantly because there's such a diverse range of applications.

I am not a scientist. I have never analyzed the far reaches of the solar system through the lens of a telescope nor scrutinized cancer cells under a microscope.

There's always something that an engineer can do to make microscopes better.

And my real enemy is not to hold the specimen sterile, but it's the lighting. The light is our real enemy. So we have to work with very very poor lighting. But we can increase the light with computers.

In 2008, the Nobel Prize in Chemistry was awarded for work done on a molecule called green fluorescent protein that was isolated from the bioluminescent chemistry of a jellyfish, and it's been equated to the invention of the microscope in terms of the impact that it has had on cell biology and genetic engineering.

Cell culture is a little like gardening. You sit and you look at cells, and then you see something and say, 'You know, that doesn't look right'.

The 31th of May, I perceived in the same water more of those Animals, as also some that were somewhat bigger. And I imagine, that [ten hundred thousand] of these little Creatures do not equal an ordinary grain of Sand in bigness: And comparing them with a Cheese-mite (which may be seen to move with the naked eye) I make the proportion of one of these small Water-creatures to a Cheese-mite, to be like that of a Bee to a Horse: For, the circumference of one of these little Animals in water, is not so big as the thickness of a hair in a Cheese-mite.

To develop drugs for people, we basically dismantle the system. In the lab, we look at things the size of a cell or two. We dismantle life into very small models.

Passing just lately over this lake, ... and examining this water next day, I found floating therein divers earthy particles, and some green streaks, spirally wound serpent-wise, and orderly arranged, after the manner of the copper or tin worms, which distillers use to cool their liquors as they distil over. The whole circumference of each of these streaks was about the thickness of a hair of one's head. ... all consisted of very small green globules joined together: and there were very many small green globules as well. [The earliest recorded observation of the common green alga Spyrogyra.]

CGI means, just to be clear, creating any type of image with a computer. Basically, starting off with nothing, or with images and manipulating them. The way we did it, everything was actual photographed images. A lot of that stuff was shot through a microscope of chemical reactions, yeast growing, lots of weird things, by Peter Parks. We put it into a computer and collaged it, manipulated it. Meaning we digitally shaped it to fit with other images. But there was no computer-generated imagery at all.

People who look for the first time through a microscope say, 'Now I see this, and then I see that,' and even a skilled observer can be fooled. On these observations I have spent more time than many will believe, but I have done them with joy, and I have taken no notice of those who have said, 'Why take so much trouble,' and, 'What good is it?'

Everything I did in high school was focused on microbiology, looking at things like algae under a microscope for hours on end. When I was 13, I saved up $100 to buy a good used microscope. I was obsessed with microorganisms.

I remember vividly my student days, spending hours at the light microscope, turning endlessly the micrometric screw, and gazing at the blurred boundary which concealed the mysterious ground substance where the secret mechanisms of cell life might be found.

With the phase-contrast method still in the first somewhat primitive stage, I went in 1932 to the Zeiss Works in Jena to demonstrate. It was not received with such enthusiasm as I had expected.

If you wanted to dissect the structure of living cells, genetic analysis was an extremely powerful method, so my interest turned to that.

My first summer in college I worked in a fruit fly lab where I had two jobs: dissect the fruit fly larvae brains and incinerate the old tubes of flies.