Why shoot for the moon? It matters because when you try to do something radically hard, you approach the problem differently than when you try to make something incrementally better.
Not all complex problems have easy solutions; so says science (so warns science.)
Every employee at Workday thinks about how they are going to help customers be successful. It is a simple formula, but a lot of companies go out, and they don't listen to their customers; they don't try to solve hard problems, making it tougher for themselves to create a great business.
Some mathematics problems look simple, and you try them for a year or so, and then you try them for a hundred years, and it turns out that they're extremely hard to solve. There's no reason why these problems shouldn't be easy, and yet they turn out to be extremely intricate.
I think the thing that I've learned is that really great people, they actually want to work on hard problems.
I'm sure that some of them will be very hard and I'll have a sense of achievement again, but nothing will mean the same to me - there's no other problem in mathematics that could hold me the way that this one did.
Don't tell me this is a difficult problem. If it weren't difficult, it wouldn't be a problem.
Whether it's mending a failing company, fighting corruption, tackling disease, or rebuilding a marriage, the hardest problems defy just-add-water remedies. Indeed, slapping on a Band-Aid when surgery is needed usually just makes things worse.
Well, some mathematics problems look simple, and you try them for a year or so, and then you try them for a hundred years, and it turns out that they're extremely hard to solve.
Of necessity, a scientist typically studies one incredibly tiny sliver of some biological system, totally ensconced within one discipline, because even figuring out how one sliver works is really hard.
Run toward the hardest problems. This approach has helped me to learn a tremendous amount from both success and failure.
When you solve big, hard problems, problems that fundamentally improve how an industry works, financial returns follow, giving you resources to do more of the same.
Usually, the best ideas come from having to fix a really hard problem.
When life is going to present you with tons of problems - really hard ones, some less hard, some debilitating - it's what you do about them that matters.
It takes a certain amount of courage to tackle very hard problems in science, I now realise. You don't know what the timescale of your work will be: decades or only a few years.
I've seen how the issues that come across a president's desk are always the hard ones - the problems where no amount of data or numbers will get you to the right answer.
Find some fun way to get a little more oil on your hands or mud on your boots. Sometimes, that's what it takes to take down some of the really big problems.