Better treatment and detection methods have also improved the survival rate for people with cancer, and for the first time in history, this year the absolute number of cancer deaths in the U.S. has decreased.
Breast cancer isn't one disease - it's probably four or five different types, and without knowing what type a person has, you can't optimize treatment for them.
I think one possibility [in the future] might be chemotherapy. And I'm always hesitant to say that because it makes it sound like I'm against chemotherapy. Right now, chemotherapy is the best cancer treatment therapy we have. But let's say we find some way where we can almost genetically engineer the DNA of our being and fight cancer that way. Then, the idea that we used to pump poison into people to fight off cancer will almost seem like the use of leeches or something.
Although not yet routine, many cancer centers have the technology to sequence some or all of a patient's cancer genome. This can provide massive amounts of valuable information about your cancer, including whether you have genetic mutations and other abnormalities for which new drugs are available.
We can get much better outcomes from people if we understand the genetic basis of the exact cancer that they have, what interventions might be most effective against it, what's worked in the past and what hasn't.
The principle of treating cancer is to kill the abnormally dividing cells. Many drugs achieve this in a relatively unselective way, killing any cell that is dividing.
We are still working with an incomplete compass. The time is right to bring the full power of genomics to bear on the problem of cancer.
What we do in the laboratory is we try to design drugs that will not just eradicate cancer cells but will eradicate their homes.
Fighting cancer is my mission right now. The research and development of finding cures for this nasty disease is my passion.
I was treated with a miracle drug, just like Lance Armstrong.
In 15 years, we've raised $225 million, sequenced the myeloma genome, and opened 45 trials of 23 drugs - six approved by the FDA - which have doubled the life span of multiple myeloma patients. I've taken both Velcade and Revlimid, which we helped develop.
I don't want 100 different cures of cancer. I want, you know, give me five. So if you had, you know, five medicines, you could do away with 90 percent of cancer. That's sort of my objective. I think we're going to do it.
Studies show that Avastin can prolong the lives of patients with late-stage breast and lung cancer by several months when the drug is combined with existing therapies.
It is becoming clear that many diseases - especially cancer - are highly complex and may respond better to a multi-drug approach which targets many different aspects of a disease process.
Genome-based treatment, based on wider and cheaper availability of genome data, will provide new ways to customize the therapeutic protocol and enhance our control over diseases and medical treatment.
I get really excited about specific therapies, personalized therapies. Like, let's say, taking a piece of someone's tumor and testing a bunch of treatments in a lab and being able to come up with the right therapy for that specific patient.
We once thought of cancer as an incurable disease; then we started treating it.
A few drugs - such as beta-blockers, statins and glycogen control medications - have proved very effective at managing hypertension, heart disease, diabetes and strokes. Most insurance plans charge something for them. Why not make drugs like these free? Not for everyone, but just the groups for whom they are provably effective.
If there's a seminal discovery in oncology in the last 20 years, it's that idea that cancer genes are often mutated versions of normal genes.
If you have lung cancer, the most important thing you can know is your genetic code.
Chemotherapy is just medieval. It's such a blunt instrument. We're going to look back on it like we do the dark ages.
By acquiring Biovex, we're continuing the transformation of Amgen into a company that supports therapeutic oncology as well as supportive care oncology.
Say you have cancer - you have this broad thing we call cancer; we're going to irradiate you and pump this poisonous material into you and hope more of the bad stuff dies than the good. That is going to seem so medieval when we can fix it on a genetic level, and Foundation Medicine is the first step to diagnosing it on a genetic level.
