Immune Tolerance Quotes

Many key concepts concerning the nature of immunity have originated from the very practical need to control virus infections.

The nature of a protective immune response to HIV is still unclear. Because in a very, very unique manner, unlike virtually any other microbe with which we're familiar, the HIV virus has evolved in a way that the immune system finds it very difficult, if not impossible, to deal with the virus.

As biologists, we contemplate with admiration and awe the wondrous array of sophisticated cell interactions and recognitions evolved in the T cell immune system, which must be a model for other similarly complex biological systems of highly differentiated organisms.

There are two main types of immunity to an infection. Innate immunity comes from circulating cells that attack any invader the body views as foreign. Adaptive immunity is specific to the pathogen presented. Through adaptive response, immune cells are programmed to secrete antibodies that are primed to target a viral invader.

I like to think that when Medawar and his colleagues showed that immunological tolerance could be produced experimentally, the new immunology was born.

Autoimmunity is probably the next frontier. The majority of cases of autoimmune disease result from a complex genetic problem that has environmental influences. It is a colossal task for the immune system to maintain tolerance to self and yet be ready to react to everything in the world around us.

The immune system has evolved the capacity to react specifically with a very large number of foreign molecules with which it had no previous contact while avoiding reactivity for autologous molecules, naturally antigenic in other species or in other individuals of the same species.

My immune system has always been overly welcoming of germs. It's far too polite, the biological equivalent of a southern hostess inviting y'all nice microbes to stay awhile and have some artichoke dip.