I always hate it when I see the wrong person in massive roles, so for me, my biggest fear would be accepting a role I thought I wouldn't find the rhythm of.
If you cast wrong, you are in a lot of trouble.
Sometimes you choose the wrong actor, he could be the best actor ever, but hes not cast in the right part then it doesnt work.
What used to frustrate me going into an audition was that some inexperienced, lesser casting people would think that actors are acting only when they're speaking.
It's weird because I once lost a job because I had a chemistry read with the lead actor, and I could tell we had negative chemistry. He was very lovely, but you could tell. We had the chemistry of two chairs.
I always have an idea before we even start the movie because if you hire the wrong person, within a couple of days you're going to know that and you're going to be really panicked.
If you cast a film incorrectly, then you're going to be fighting an uphill battle.
If you're ever making a television show, don't cast smart actors because they are just a pain in the ass. The moment you start to bullshit them you've lost them, so you have to either know what you're talking about or when you don't talk to them.